|
KMID : 0043320070300111404
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1404 ~ p.1409
|
|
|
Cytotoxic and DNA Topoisomerases I and II Inhibitory Constituents from the Roots of Aralia cordata
|
|
Seo Chang-Seob
Li Gao
Lee Chong-Soon
Jahng Yurng-Dong
Son Jong-Keun
Kim Cheorl-Ho
Chang Hyun-Wook
|
|
|
Abstract
|
|
|
|
Bioactivity-guided fractionation, based on the DNA topoisomerase inhibitory activity, lead to the isolation of five compounds (1-5) from the methylene chloride extract of the roots of Aralia cordata Thunb. (Araliaceae). These compounds were identified as ent-pimara-8(14),15-dien-19- oic acid (1), ent-pimara-8(14),15-dien-18-oic acid (2), 16?hydrogen-17-isovaleryloxy-ent-kauran- 19-oic acid (3), 16?hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (4) and dehydrofalcarindiol- 8-acetate (5) from their spectral data. Compound 3 was isolated for the first time from this plant, and also showed the strongest inhibition of both DNA topoisomerase I and II activities, with 53 and 96% inhibitions, respectively, at a concentration of 20 킡. However, all the compounds exhibited either weak or no cytotoxicities against the human colon carcinoma cell line (HT-29), the human breast carcinoma cell line (MCF-7) and human hepato blastoma cell line (HepG-2).
|
|
|
KEYWORD
|
|
|
Aralia cordata, Araliaceae, Diterpene, DNA topoisomerases I and II inhibitor, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|